Cytomegalovirus (CMV) in Newborns

CMV (cytomegalovirus) is a herpes
virus. It’s very common. It affects people of all ages and in all parts of the U.S.
In
most cases, CMV causes mild symptoms, or no symptoms at all. But it can cause serious
problems in an unborn baby or newborn.

CMV is a virus that spreads from a
person with the virus to someone else. The virus can spread:

• To the unborn baby from the mother during pregnancy (congenital CMV)
• To the newborn from the mother during delivery or through breastmilk (perinatal CMV)
• In households with young children and
  in daycare centers
• By contact with infected saliva, urine, vaginal fluid, or semen

Congenital CMV

Most babies with CMV that is
present at birth (congenital CMV) don’t have symptoms. If present, symptoms may
include:

• Hearing loss (this may be found
  during regular newborn hearing screening)
• Small size, including small head
  size
• Enlarged liver and spleen
• Yellow color to skin
  (jaundice)
• Small broken blood vessels under
  the skin
• Eye problems

Perinatal CMV

Babies with CMV that is passed
along during birth or through breastmilk (perinatal CMV) may not have symptoms. Signs
and symptoms are usually seen only in very premature or sick newborns between 3 weeks
and 6 months of age. They may include:

• Abnormal blood test results. For
  example, the results may show low platelet levels, low white blood cell counts, or
  abnormal liver function.
• Enlarged liver and spleen
• Swelling (inflammation) of the
  lungs (pneumonitis)

The symptoms of CMV may look
like other health conditions. Talk with your baby’s healthcare provider if you think
your baby may have CMV infection.

Most CMV infections in the mother are not diagnosed because the virus causes few symptoms.
Tests for diagnosis include:

• In the fetus, amniotic fluid or fetal blood may be checked for CMV.
• In the newborn within 3 weeks from birth, urine and saliva cultures may find CMV.

Other tests may include:

• Blood tests, including complete blood
  count (CBC), liver function tests, and tests that can find the virus in the blood
  or
  signs of past infection in the blood
• CT scan of the brain
• Hearing exams
• Eye exams

Treatment will depend on your
child’s symptoms, age, and general health. It will also depend on how severe the
condition is. In general, treatment is not recommended for healthy newborns with no
symptoms.

Treatment for newborns with
symptoms is controversial.

Treatment with medicine that works against the virus (ganciclovir or valganciclovir)
is recommended for some babies with CMV. Babies may get this treatment if they have
the following:

• Swelling of the lungs
• Very low platelet counts
• Eye problems that may lead to vision
  loss
• Hearing loss

Babies with hearing loss or small head size may take ganciclovir long-term.

Possible complications of CMV may include:

• Nervous system problems, like seizures
• Problems with growth and development
• Feeding problems

Because it is so common, it’s hard
to prevent a CMV infection. These measures may help to prevent CMV infection, especially
in pregnant women:

• Wash hands with soap and water, especially after changing diapers, feeding children,
  wiping a child’s nose or mouth, or touching toys.
• Don’t kiss young children on the
  mouth.
• Don’t share forks, spoons, cups, or food with young children.

• CMV can be passed to an unborn baby during pregnancy. It can be passed to a newborn
  during delivery or in breastmilk.
• Most babies with congenital CMV have no symptoms. 
• CMV can cause serious problems in the
  unborn baby and newborn.
• Some newborns with CMV may be treated with antiviral medicine.
• Washing hands with soap and water works well to remove the virus from the hands to
  prevent spreading CMV.

Tips to help you get the most from a visit to your child’s healthcare provider:

• Know the reason for the visit and what you want to happen.
• Before your visit, write down questions you want answered.
• At the visit, write down the name of a
  new diagnosis and any new medicines, treatments, or tests. Also write down any new
  instructions your provider gives you for your child.
• Know why a new medicine or treatment is prescribed and how it will help your child.
  Also know what the side effects are.
• Ask if your child’s condition can be treated in other ways.
• Know why a test or procedure is recommended and what the results could mean.
• Know what to expect if your child does not take the medicine or have the test or procedure.
• If your child has a follow-up appointment, write down the date, time, and purpose
  for that visit.
• Know how you can contact your child’s provider after office hours. This is important
  if your child becomes ill and you have questions or need advice.