Infertility is a problem of the
reproductive system. It affects the body’s ability to reproduce. It could be caused by a
problem with the man’s system, the woman’s system, or both. For a pregnancy, these must

  • The man must make healthy sperm.
  • The woman must make healthy eggs.
  • The fallopian tubes must be open to let the sperm to reach the egg.
  • The sperm must be able to fertilize the egg.
  • The fertilized egg must implant in the uterus.
  • The embryo must be healthy.

Infertility is not just a woman’s
concern. Half the time, a male factor causes or is a part in the problem. Many couples
have more than 1 factor that plays a role.

In a few cases, a cause for infertility can’t be found.

If you think you are not able to
get pregnant, see your healthcare provider soon. The age of the woman and how long you
have been trying to get pregnant may affect treatment.

Many things can cause infertility.
It can be a problem in the female reproductive system. It can be a problem in the male
reproductive system. Or it may be both. Below are things that can affect fertility.

Female factors

  • Ovulation
    The woman doesn’t make enough hormones to develop, mature, and release a
    healthy egg.
  • Anatomical problems. A problem with the woman’s anatomy can
    prevent the egg and the sperm from meeting. The most common problem is blocked
    fallopian tubes. Other problems may include scar tissue in the pelvis from past
    surgeries or infections.
  • Endometriosis.The tissue that lines the uterus implants outside the uterus in this
    condition. It usually implants on other reproductive organs or in the belly. Each
    month, this misplaced tissue reacts to the hormone changes of the menstrual cycle.
    This means it builds up, breaks down, and bleeds. This can cause scar tissue to
    form and affect fertility.
  • Birth
    Certain birth defects can affect fertility. One of the most common problems
    happens when a female baby is exposed to DES (diethylstilbestrol) in her mother’s
    womb. Pregnant women in the 1940s and 1950s took this medicine to prevent
    pregnancy loss. But it was found to cause problems with the development in the
    uterus and cervix in the baby. This would later hurt her ability to get pregnant
    as a woman.
  • Infection.Pelvic inflammatory disease (PID) is caused by a type of bacteria such as
    gonorrhea and chlamydia. PID can affect the uterus, fallopian tubes, the ovaries,
    or all of these. It causes scar tissue to grow between organs. This leads to
    ongoing pelvic pain and raises the risk for an ectopic pregnancy. This is when the
    fertilized egg implants outside the uterus.
  • Immune
    system problems.
    A problem with a woman’s immune system can lead to pregnancy loss. Antibodies
    in a woman’s system can fail to recognize a pregnancy. Or there may be an abnormal
    immune response to the pregnancy. Women can also develop antisperm antibodies,
    which attack and destroy sperm.

Male factors

  • Low or no
    sperm production.
    Without enough healthy sperm, the chance of fertilization is decreased.
  • Abnormal
    sperm function.
    Sperm must be able to swim and penetrate the egg.
  • Varicocele.This is a condition in which varicose veins develop around the testes. It’s a
    very common cause of infertility in men. It’s treated with surgery.
  • Hormone
    Hormone problems can affect sperm production and fertility.
  • Chromosome defects.Some defects are linked to male infertility.
  • Birth
    Problems in a man’s reproductive system can happen in the womb. Some birth
    defects are due to a man’s exposure to DES (diethylstilbestrol) taken by his
    mother during pregnancy.
  • Immune
    system problems.
    A man may have antisperm antibodies. These attack
    and destroy sperm.

These lifestyle habits can also affect sperm quality and function:

  • Use of recreational drugs such as marijuana or cocaine
  • Heavy alcohol use
  • Smoking
  • Taking certain medicines
  • Too much heat to the genital area, such as using a hot tub

A couple is defined as infertile if conception does not happen in these cases:

  • After 1 year of unprotected sex
  • After 6 months in women over age 35
  • If there are known problems causing infertility

To diagnose infertility, both the man and the woman are tested.

Some healthcare providers can do a
basic infertility evaluation. But, many causes of infertility are best treated by a
reproductive endocrinologist. This is an OB/GYN who has had education and training in
infertility. He or she should be certified with the American Board of Obstetrics and

The healthcare provider will test
both partners to find the cause of infertility. The healthcare provider is looking for
answers to these questions:

  • Is the woman ovulating regularly?
  • Is the man making healthy sperm?
  • Are the woman’s egg and the man’s
    sperm able to unite and grow normally?
  • Are there any problems with implantation?
  • Is the woman able to maintain the

The below tests are often part of
the basic testing for infertility.

Both partners


  • Physical
    You will have a full physical exam. This includes a Pap test and testing for
  • Ovulation
    You can check to see if you are ovulating by keeping a
    basal body temperature chart. This is your morning body temperature. Other
    ovulation prediction methods use urine samples.
  • Hormone
    Hormone testing may be advised. Some hormones increase and decrease at
    various times in the monthly cycle.
  • Ultrasound.This can show the follicles on the ovaries. These are the sacs that contain
    the developing eggs. It can also show the thickness of the uterine tissues. Your
    healthcare provider can also check for problems such as ovarian cysts or
  • X-rays.
    A hysterosalpingogram may be advised. For this test, a dye is injected
    into the cervical opening to see inside the uterus. This lets the radiologist see
    if the fallopian tubes are open.


A semen sample is taken and tested in the lab. The healthcare
provider can:

  • Check the sperm count
  • Test sperm motility
  • Check the shape of sperm
  • Assess the ejaculate liquid

Other tests may be done that
test the sperm’s ability to penetrate the egg, as well as male hormone testing.

Men may need to see a urologist
for more testing.

Once a diagnosis is made, you can
work with a fertility expert to find the best treatment. Most people with infertility
are treated with medicine or surgery. Depending on the cause, there are many types of

Types of treatments for women may

  • Intrauterine
    This method is done with a small flexible tube called a catheter. The tube is
    used to place washed and prepared sperm into the uterus. It may be used for low
    sperm count or cervical mucus problems. This method is often used along with
    ovulation medicines.
  • Ovulation
    These help regulate the timing of ovulation. They stimulate the growth and
    release of mature eggs. They can also help correct hormone problems that can affect
    the lining of the uterus. Ovulation medicines can cause more than 1 egg to be
    released. This raises the chance of having twins or more. Some of the common
    medicines include:

    • Clomiphene citrate
    • Human menopausal gonadotropins
    • Medicines with
      follicle-stimulating hormone (FSH) and luteinizing hormone (LH)
    • Follicle-stimulating hormone
  • Surgery.
    Surgery may be used to treat or repair a condition such as blocked
    fallopian tubes or endometriosis. This may be done using laparoscopy. In a
    laparoscopy, a small cope is inserted into the abdominal or pelvic area. This lets
    the healthcare provider see internal organs. Some methods to treat infertility can be
    done using small tools put through the laparoscope.
  • Assisted
    reproductive technology (ART).
    For some couples, more extensive treatment is needed. With most forms of ART,
    the sperm and egg are joined in the lab. The fertilized egg is then returned to the
    woman’s uterus where it can implant and grow. While ART procedures are often costly,
    many are being used with success.

Types of ART include:

  • In vitro
    fertilization (IVF).
     This is done by removing a woman’s eggs and
    fertilizing them in the lab with sperm. The embryo is then transferred into the
    woman’s uterus through the cervix. Most couples transfer 2 embryos. More may be
    transferred in certain cases. IVF is the most common form of ART. It’s often the
    treatment of choice for a woman with blocked, severely damaged, or absent fallopian
    tubes. IVF is also used for infertility caused by endometriosis or male factor
    infertility. IVF is sometimes used to treat couples with long-term unexplained
    infertility who have not been able to get pregnant with other treatments.
  • Intracytoplasmic sperm injection (ICSI). In this procedure, a single
    sperm is injected directly into an egg. This method is most commonly used to help
    with male factor infertility problems.
  • Gamete
    intrafallopian transfer (GIFT).
    This is done with a fiber-optic
    instrument called a laparoscope to guide the transfer of unfertilized eggs and sperm
    into the woman’s fallopian tubes through small incisions in her abdomen. GIFT is only
    used in women with healthy fallopian tubes.
  • Zygote
    intrafallopian transfer (ZIFT).
     This is done by fertilizing a woman’s
    eggs in the lab. Then the laparoscope guides the transfer of the fertilized eggs
    (zygotes) into her fallopian tubes. ZIFT is only used in women with healthy fallopian
  • Donor
     This is done by transferring an embryo from a donor to an
    infertile woman. The donor gives up all parental rights to any resulting children.
    ART using donor eggs is more common in older women. The chance of a fertilized egg
    implanting is related to the age of the woman who produced the egg. Egg donors are
    typically in their 20s or early 30s.
  • Embryo
     In this method, the embryos are frozen for transfer
    at a later date. This is often used when an IVF cycle produces more embryos than can
    be transferred at 1 time. The remaining embryos can be transferred in a future cycle
    if needed.

Types of treatments for men may

  • Assisted
    reproductive technologies (ART).
    This type of treatment may include:

    • Artificial insemination.This is done by placing large numbers of healthy sperm either at the
      opening of the cervix or into the woman’s uterus.
    • IVF,
      GIFT, and other methods.
      These have been used for the treatment
      of male infertility. As is the case with artificial insemination, IVF and
      similar techniques offer the chance to prepare sperm in a lab. In the lab, the
      eggs are exposed to the best concentration of high quality, motile sperm.
    • Microsurgical fertilization.This includes microinjection methods, such as intracytoplasmic sperm
      injection (ICSI). For this treatment, a single sperm is injected into an egg.
      Fertilization then takes place under a microscope.
  • Medicine
    A few infertile men have a hormone problem that can be
    treated with hormone therapy. Hormone imbalances caused by a problem with the
    hypothalamus, the pituitary gland, and the testes directly affect the development of
    sperm. Medicine therapy may include gonadotrophin therapy, antibiotics, or another
  • Surgery.
    Surgery for male infertility is done to repair anatomical problems that
    impede sperm production and maturation or ejaculation. Surgery to remove varicose
    veins in the scrotum (varicocele) can sometimes improve the quality of sperm.
  • Infertility is a problem of the reproductive system. It impairs the body’s ability to reproduce. It could be caused by a problem with the man’s system, the woman’s system, or both.
  • Infertility is not just a woman’s concern. In about half of infertile couples, the male is the sole cause.
  • The couple are believed infertile if conception does not happen after 1 year of unprotected sex, after 6 months in women over age 35, or if there are known problems causing infertility.
  • Many causes of infertility are best treated by a board-certified reproductive endocrinologist.
  • Depending on the cause of infertility, there are many treatment choices for an infertile couple.
  • Treatment with medicine or surgical repair cure most cases of infertility.

Tips to help you get the most from a visit to your healthcare provider:

  • Know the reason for your visit and what you want to happen.
  • Before your visit, write down questions you want answered.
  • Bring someone with you to help you ask questions and remember what your provider tells you.
  • At the visit, write down the name of a new diagnosis, and any new medicines, treatments, or tests. Also write down any new instructions your provider gives you.
  • Know why a new medicine or treatment is prescribed, and how it will help you. Also know what the side effects are.
  • Ask if your condition can be treated in other ways.
  • Know why a test or procedure is recommended and what the results could mean.
  • Know what to expect if you do not take the medicine or have the test or procedure.
  • If you have a follow-up appointment, write down the date, time, and purpose for that visit.
  • Know how you can contact your provider if you have questions.